Autoimmune Diseases

The major cause of chronic diseases

Dr. Dimitris Tsoukalas, MD
 
Autoimmune diseases occur when our body attacks and destroys its own cells and organs. One out of ten citizens in the European Union suffers from an autoimmune disease.

Today they constitute the main cause of chronic diseases and affect the health of more people than cardiac diseases or cancer.

American Association of Autoimmune Related Diseases (AARDA) data indicate that fifty million Americans, 1 out of 5, suffer from an autoimmune disease and the numbers seem to be similar for the European population.

Diseases such as:

- Multiple sclerosis
- Diabetes
- Rheumatoid arthritis
- Hashimoto's thyroiditis
- Psoriasis
- Ulcerative colitis
- Crohn's disease
- Lupus erythematosus
- Dermatitis
- Muscular diseases  
- ALS

belong to the category of autoimmune diseases and have increased dramatically over the last 15 years. They are chronic diseases, for which the person suffering should take complex pharmaceutical formulations for the rest of their lives.

Why is this happening  


According to new studies, the higher the standard of living, the greater the effect of autoimmune diseases; they are the price we pay for a way of living that is constantly distancing itself from normal.

In order to understand what happens exactly, we should examine the issue at the point where it occurs. At the cellular level.

Our c
ells are the biological units of which our body is comprised. Colonies of cells with common characteristics are accumulated and form organs and finally a human body.

The operating condition of our cells reflects our general health condition.

A cell is comprised of structural elements and at the same time, u
ses some more to function. They are components we receive via food and are necessary for our cells to exist and function properly Components like that are minerals, amino acids, proteins, vitamins, enzymes, fat and carbohydrates.

But can food nowadays provide us with the compounds a healthy body needs in quantity and quality, in order to construct its tissues and perform the necessary cellular functions that are typical of life?
 
Our foods have changed


W
ithin just fifty years, the change that our diet has undergone is immense.

Let us examine a food like lettuce, for instance. In the past, we had a plot and cultivated a hundred lettuces in it. Today, within the same land, a thousand lettuces are cultivated. The nutrients of the land have to be split to a thousand lettuces instead of a hundred, as it happened once.

In order to have production, the use of fertilizers that restore the necessary components of the soil is unavoidable. In no case can fertilizers provide the 92 minerals available in nature, though. The conventional cultivations enrich soil using three basic minerals
 for plant growth (nitrogen, potassium and phosphorus) whereas the best biological cultivations reach up to merely sixteen.

In order to receive the nutrients a lettuce provided us only fifty years ago, today we have to consume ten.


However, this is not easy to achieve. The same applies to the rest of the foods we consume, either vegetal or animal.

So our cells, do not receive and do not dispose of the elements they need to function. Gradually, deficiencies are created at a cellular and molecular level.

Components that should be within the cell are now absent.
 Of course, life never depends on one metabolic pathway. There are alternatives. But the second alternative is never as efficient as the first one.

As the efficiency is reduced, so is our health. We do not feel as good as we used to. Each day that passes we distance ourselves from the optimal operating state. We often believe that this is due to the years passing by. Unfortunately, though, it is now easy to observe that similar problems increasingly affect younger people.

The problem does not stop at this point. Apart from the deficiencies our cells present, we are charged with toxic substances that should not be present. Heavy metals, industrial chemicals, drugs and other substances foreign to life are introduced to each of our cells. (Xenobiotic Substances)

Our cells have changed


The image of our cells is constantly distancing itself from its initial healthy condition.

Components that should be included are now absent and others, foreign to life, that should not be present, are.

Recent research suggests that the change of biochemical composition of the inside of the cells is accompanied by a change of the membrane and the external image of the cell.  

As a result of the above, the body does not recognize these cells any longer as pertaining to it and attacks them!

Depending on heredity, environment and dietary choices, cells that distance themselves more than normal are the first ones to be attacked. In many cases, the body attacks more than one organs or systems.




The substantial solution is to restore the natural operation and manage the actual cause of the problem.

What can we do

1. Highly specialized metabolomic analysis guide us to the restoration of the natural state of our cells. According to Harvard Medical School, metabolomics is the simplest and most accurate way to evaluate the health condition of the individual nowadays. The concomitant restoration of the healthy functions with the use of the recommended pharmaceutical treatment, where necessary, gives us a very powerful weapon in the fight against autoimmune diseases.

2. To help the person detect and manage stress agents that are hidden behind the disease. This is an issue that most people ignore and often remains unmanaged. Almost always autoimmune diseases are accompanied by intense changes of mood which refeed the disease and deteriorate the image.    

The biochemical alteration and the stress of the contemporary environment are the basic causes of the tremendous increase of autoimmune diseases. Their gradual restoration may lead to a steady improvement of the image instead of a steady deterioration.

Our body is genetically programmed to be healthy; the duty of medicine and ours is to assist it to this effort. Recent scientific knowledge allows and encourages us to follow and support the work of nature.


To Your Health!

 



References
  1. American Autoimmune Related Diseases Association, statistics, AARDA. Accessed on Nov. 2018 
  2. World Economic Forum global report. 10 Emerging technologies 2018
  3. U.S. National Library of medicine. What is the Precision Medicine Initiative?
  4. World aging population, chronic diseases and impact of modifiable-metabolic risk factors Dr. Dimitris Tsoukalas, MD (Greece). European Institute of Nutritional Medicine, E.I.Nu.M. 20th International Congress of Rural Medicine 2018. Tokyo - Japan.
  5. The Akt pathway in oncology therapy and beyond (Review). Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, Spandidos DA, Margina D. Int J Oncol. 2018 Oct 16. doi: 10.3892/ijo.2018.4597.
  6. Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance. Zheng Liu Kevin Maas Thomas M. Aune Human Molecular Genetics 2006.
  7. Autoimmune disease: why and where it occurs. Philippa Marrack, John Kappler & Brian L. Kotzin Nature Medicine volume 7, pages 899–905 (2001)
  8. Role of “Western Diet” in Inflammatory Autoimmune Diseases Arndt Manzel et. al. Curr Allergy Asthma Rep. 2014 Jan; 14(1): 404.
  9. Environment and Disease Risks Stephen M. Rappaport and Martyn T. Smith. SCIENCE, EPIDEMIOLOGY 22 OCTOBER 2010 VOL 330.
  10. Current Concepts in Autoimmunity and Chronic Inflammation. Andreas Radbruch, ‎Peter E. Lipsky - 2006 - ‎Medical.
  11. Hygiene Hypothesis and Autoimmune Diseases Clinical Reviews in Allergy & Immunology Graham A. W. Rook 2012.
  12. Metabolic pressure and the breach of immunological self-tolerance Veronica De Rosa et al. Nature Immunology (2017).
  13. Application of metabolomics in autoimmune diseases: Insight into biomarkers and pathology. J. Kang et al. / Journal of Neuroimmunology 279 (2015) 25–32
  14. Autoantigens in systemic autoimmunity: critical partner in pathogenesis A. Rosen and L. Casciola-Rosen J Intern Med. 2009 Jun; 265(6): 625–631.
  15. Metabolomic biomarkers: their role in the critical path Laura K. Schnackenberg, Richard D. Beger.US. Food and Drug Administration. Feb 2009.
  16. Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? Shani Dahan, Yahel Segal1 and Yehuda Shoenfeld. NATURE REVIEWS | RHEUMATOLOGY. 13 Apr 2017.
  17. Eric F. Morand New evidence strengthens the hypothesis that exposure to trauma and the associated physiological responses contribute to the development of autoimmune diseases, including systemic lupus erythematosus. NATURE REVIEWS | RHEUMATOLOGY. Jan. 2018
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